When I can I like to drive while towing about 60 mph. 58 is optimum for towing. In California, it's 55 mph for any towing vehicle, and I like it. I can look around a little more without fearing for my life, relax and enjoy the trip better.
Above 65 mph, for me, is asking for it when towing. RV tires like to explode when they are hell hot and above 70 mph. I keep a good eye on tire pressures, especially when it is hot. Say I fill my tires to correct pressure in Alaska, where it's cooler, say 60 F. or so. Then head south (we did this trip in 2019, Alaska to Florida and back), somewhere in Texas I checked the RV tires, holy shit! let off some air pressure, it can climb when those tires are 100 F plus, they get warm just from driving, let alone a scorching hot paved road that can be well past 100 F.
I used to have a CDL in my working days, and drove dump trucks with pup trailers for some time back in the 1980,s. For those big rigs, speed will get you into big trouble fast. I have no problems driving at a slower rate.
@Captainmal, you mpg towing is pretty close to my CTD, it's right in there at 13 mpg give or take a couple of tenths.
I've pushed grease past the seals myself with those Dexter EZ-Lube axles. One of my trailer axles has no brakes, just hubs, and you can see some grease on the insides of the wheel sometimes. The trick is before greasing, do it on a nice warm day, put your grease tubes and grease gun in the sun, let them get warm first. Then the grease flows like hot butter, and it works pretty good. I had problems doing this on a cooler days, ie, springtime in Alaska it's not too warm yet. Cold grease is stiff and don't flow good.
And carry lots of spare parts, hub caps(they fall off from time to time), bearings (Timkins only, made in the USA) and seals, spare nuts, locks, etc, everything. I have a large thread die I can chase the threads for the spindle, along with a good file. When you burn up a bearing, it is likely you will spin the bearing race, and your axle will never be right when it takes a file to get the new bearing on. I also carry a set of bearing and seal drivers and a good ballpeen hammer.
Ask me how I know this, Lol.
On the side of the freeway somewhere in North Carolina. We had just gotten on the freeway from a pit stop. I had just walked around the wheels too, I look at them all the time, give them a good wiggle to check for looseness. I'm talkin just a few minutes, when they go they go fast and right now. The grease melts, the cap falls off, grease flings everywhere, and those bearings get red hot and that's all folks. The last two times this has happened, I could smell the hot grease right before I pulled over, even from back there on the RV at 60 mph. I could also hear the bearing noise, this strange grinding sound. If you're paying attention, and are quick about it, you can save the axle if caught soon enough. A trucker tooted his horn at me pointing to the smoking bearing, thanks dude! But I did smell the hot grease right before he hit his horn. RV,s can be a PITA. I always carry two trailer spare tires. Just in case.