Some excellent advice has been given in this thread. I want to add my own experience dealing with towing and my ecodiesel as well as experiences I have had with other peoples vehicles and towing. My wife and I rent travel trailers. Because of this we not only tow a lot (20,000-30,000 miles a year), we work with a lot of different people with different vehicles. We have had 4 customers call us and complain that they had to pull over to let their vehicles cool down when towing our 8000lb trailer. All 4 were GMs. 3 were Suburbans, and 1 was a Tahoe. 2 of them had cruise set at 75, and attempted to "set it and forget it" and that didn't work so well for them. One of them yelled and cursed at me on the phone, claiming my trailer weighed more than I said it did and his vehicle never had any issues towing their utility trailer (which was single axle and weighed no more than 3klbs fully loaded). I told him that if he wanted to go to a scale and weigh the trailer with and without his equipment in it, and let me know what the weights were, I would gladly refund him the rental fee if the trailer was more I told him it was. He decided to drive a little slower and luckily didn't have any issues the rest of their weeklong trip.
My brother is a huge GM fan and they have a 2008 suburban with the 6.0 v8. He towed their trailer, which was about 1000lbs less than mine, behind us as we journeyed 200 miles to a location in UT for a family camping trip. 6 people in my truck, 7 in his suburban. But again, my trailer weighed about 1000lbs more. He was unable to keep up with my truck going up a 6% grade that lasted about 2 miles. And after the grade, he had a warning his transmission was overheating. He had to stop and let it cool and me and my family continued on. We ultimately made it to our destination an hour and a half before he did and we had 0 problems.
We have had over 300 people rent our trailers over the last few years. By far the majority of our renters drive f150s. We haven't had any of them experience any vehicle issues while towing. The Ecoboost engines perform very well, as do the new 10 speeds. However, they all complained about their fuel economy. The 3.5 ecoboosts were all in the 6-8mpg ranges, and the 2.7 ecoboost have been in the 7-10mpg range.
My ecodiesel is always in the 12-16mpg range, depending on which trailer I'm towing, which route I'm taking and how fast I want to go. I towed my 8000lb trailer from St George UT, to my home in Eagle Mountain, UT, which is about 290 miles, and got a hand calculated 14.6mpg for that trip. I stayed in the 55-66mph range.My oil didn't go above 238.
If you learn how to treat your truck when towing, what its limits are and stay within them, you will be very happy towing with the ecodiesel. As mentioned above, a WDH is HIGHLY recommended for towing. In some states, its required and we have found renting trailers that without one, insurance may not cover you if in an accident. If you expect to hook up a trailer and drive 75+ everywhere you go, this isn't going to be the truck for you.